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The University of Oklahoma Health Sciences Center EHSO Manual 2017-2018

22 - Appendix A - Cytotoxic/Antineoplastic Agents

AGENT                                                                             TRADE NAME

Abacavir

Abiraterone

Ado-trastuzumabemtansine

Afatinib

Aldesleukin (rIL-2)                                                             Proleukin

Alemtuzumab                                                                    Campath

Alitretinoin                                                                          Panretin

Altretamine                                                                        Hexalen

Aminoglutethimide

Amsacrine      

Anastrozole                                                                       Arimidex

Apomorphine

Arsenic Trioxide*                                                               Trisenox

Asparaginase/L-Asparaginase                                          Elspar

Axitinib

Azacytidine                                                                        Azacytidine

Azathioprime                                                                     Azathioprine

Bexarotene                                                                        Targretin

Bicalutamide                                                                     Casodex

Belinostat

Bleomycin/Bleomycin Sulfate                                                Blenoxane      

Bosutinib

Brentuximabvedotin

Busulfan                                                                            Myleran

Cabazitaxel

Capecitabine                                                                     Xeloda

Carboplatin                                                                        Paraplatin

Cabozantinib

Carfilzomib

Carmustine (BCNU)                                                         BiCNU

CCNU                                                                               Belustine

Clomiphene*

Chlorambucil*                                                                   Leukeran

Chloramphenicol

Chlornaphazin

Chlorotrianisene

Chlorozotocin

Cisplatin/Cis-Platin                                                            Platinol

Cladribine (2-chlorode-oxyadenosine, 2CdA)                  Leustatin

Crizotinib

Cyclophosphamide*                                                          Cytoxan, Neosar

Cyclosporin

Cytarabine (ara-C)/Cytosine Arabinoside                         Cytosar-U                                    

Dabrafenib

Dacarbazine                                                                      DTIC, DIC, DTIC-Dome

Dactinomycin (Actinomycin-D)                                        Cosmegen

Daunomycin*

Daunorubicin/Daunorubicin Hydrochloride                       Cerubidine

Daunorubicin (Liposomal)                                                 DaunoXome

Deferiprone

Denileukin Diftitox                                                             Ontak

 

Dexrazoxane

Diethylstilbesterol       

Docetaxel                                                                          Taxotere

Doxorubicin                                                                       Adriamycin

Doxorubicin Hydrochloride Liposomal Injection               Doxil

Epinephrin (excluding Epinephrin salts)*                         

Epirubicin/Epirubicin Hydrochloride                                  Ellence

Eribulin

Erlotinib

Eslicarbazepine

Estradiol

Estramustine                                                                     Emcyt

Ethinyl Estradiol

Etoposide (VP-16-213)                                                     VePesid

Exemestane                                                                      Aromasin

Enzalutamide

Fingolimod

Floxuridine

Fluconazole

Fludarabine/Fludarabine Phosphate                                 Fludara

Fluorouracil/5-Fluorouracil                                                Adrucil

Flutamide                                                                          Eulexin

Fosphenytoin

Fulvestrant

Ganciclovir

Gemcitabine                                                                      Gemzar

Gemtuzumab Ozogamicin                                                Mylotarg

Goserelin/Goserelin Acetate                                             Zoladex

Histrelin

Hydroxyurea                                                                     Droxia, Mylocel

Ibritumomab Tiuetan                                                         Zevalin

Icatibant

Idarubicin                                                                           Idamycin

Ifosfamide                                                                         Ifex

Imatinib Mesylate                                                              Gleevec

Interferon-A/Interferon Alfa (2a, 2b)                                 Roferon-A, Intron-A

Interleukin-2 (IL-2)

Irinotecan (CPT-11)                                                          Camposar

Isotretrinoin

Ixazomib

Letrozole                                                                            Femara

Leuprolide/Leuprolide Acetate                                          Lupron, Lupron Depot

Levamisole                                                                        Ergamisol

Liraglutide Recombinant

Lomitapide

Lomustine (CCNU)                                                           CeeNu

Macitentan

Mechlorethamine (Nitrogen Mustard)                              Mustargen

Mechlorethamine Hydrochloride

Medroxyprogesterone/Medroxyprogesterone Acetate    Provera

Megestrol/Megestrol Acetate                                            Megace

Melphalan*                                                                        Alkeran

Mercaptopurine (6-MP)                                                    Purinethol

Methimazole

Methotrexate (MTX)                                                         Mexate, Folex

Methyl-CCNU                                                                   Semustine

Mipomersen

Misoprostol

Mithramycin                                                                      Mithracin

Mitomycin

Mitomycin C*                                                                    Mutamycin

Mitotane

Mitoxantrone                                                                     Novantrone

Myleran

Nafarelin

Nevirapine

Nicotine*

Nilutamide                                                                         NIlandron

Nitrogen Mustard                                                              Mustargen

Nitroglycerin*

Oprelvekin                                                                         Neumega

Ospemifene

Oxaliplatin Paclitaxel                                                         Taxol

Pamidronate

Panobinostat

Paliperidone

Pasireotide

Pegaspargase

Peginesatide

Pentostatin (2-deoxycoformycin, DCF)                           Nipent

Pertuzumab

Phentermine*

Phenytoin

Physostigmine*

Physostigmine salicylate*

Pipobroman

Plicamycin

Pomalidomide

Ponatinib

Procarbazine/Procarbazine Hydrochloride                       Matulane

Propylthiouracil

Regorafenib

Ribavirin

Riociguat

Rituximab                                                                          Rituxan

Spironolactone

Streptozocin (Streptozoticin)*                                           Zanosar

Temazepam

Tamoxifen/Tamoxifen Citrate                                          Nolvadex

Temozolomide                                                                  Temodar

Teniposide                                                                         Vumon

Teosulfan

Testolactone

Thioguanine

Thiotepa                                                                            Thioplex

Topiramate

Topotecan                                                                         Hycamtin

Toremifene/Toremifene Citrate                                        Fareston

Trametinib

Trastuzumab                                                                     Herceptin

Teriflunmide

Tretinoin (ATRA)                                                               Vesanoid

Triethylene Thiophosphoramide                                       Thiotepa

Trifluridine/tipiracil (combination only)

Triptorelin Pamoate                                                           Trelstar Depot

Tofacitinib

Ulipristal

Uracil Mustard*                                                                 Uramustine

Valrubicin

Vandetanib

 

Vemurafenib

Vidarabine

Vinblastine/Vinblastine Sulfate                                          Velban

Vincristine/Vincristine Sulfate                                           Oncovin

Vindesine

Vinorelbine/Vinorelbine Tartrate                                        Navelbine

VM-26

Voriconazole

Vismodegib

Warfarin*

Zidovudine                                                                         Retrovir

Ziv-aflibercetp

 

*These agents are listed by the Environmental Protection Agency as hazardous wastes and must be disposed of as such

 

Sources:                American Hospital Formulary Service Drug Information 1995

American Hospital Formulary Service Drug Information 2002

Occupational Safety and Health Administration (OSHA) Instruction PUB 8-1.1 Appendix A, Work Practice Guidelines for Personnel Dealing with Cytotoxic (Antineoplastic) Drugs, January 29, 1986

OSHA Instruction CPL 2-2.20B CH-4, Chapter 21, Controlling Occupational Exposure to Hazardous Drugs, April 14, 1995

OSHA Technical Manual Section VI, Chapter 2 Appendix VI:2-1, Some Common Drugs that are Considered Hazardous

Environmental Protection Agency Regulation 40 CFR 261.33

Oklahoma Department of Environmental Quality Instructions for Disposal of Antineoplastic (Chemothera­py) Agents at Permitted Biomedical Waste Incinerators

Adams, Val  R., “Guide to Cancer Chemotherapeutic Regimens,” Pharmacy Practice News, October 2002 Supplement, pp. 29-46.

Adams, Val  R., “Guide for the Administration and Use of Cancer Chemotherapeutic Agents 2003,” Oncology Special Edition, Vol 6, 2003, pp.  123-138.

Department of Health and Human Services, CDC, NIOSH. NIOSH List of Antineoplastic and Other Hazardous Drugs in Healthcare Settings, 2014.

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